_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

This monograph consists of five parts: (1) introductory material including a conference overview; (2) papers presented at an international symposium on the topic of ethical issues in disability and rehabilitation as a section of the Annual Conference of the Society for Disability Studies; (3) responses to the symposium, prepared by four of the participants; (4) selected additional papers which offer views from perspectives or cultures not represented at the Denver conference; and (5) an annotated international bibliography. Representatives from 10 countries (...) discussed ethical issues and decision making in disability and rehabilitation. Conference papers include: "Genetic Engineering--The New Eugenics? Evolving Medical Attitudes towards the Quality of Life" (Hugh Gallagher);"Description of the Decision-Making Project" (Daryl Evans); "Treatment and Nontreatment Decisions with Respect to Extremely Premature, Very Low Birthweight Infants (500-750g)" (Ernle Young); "Allocation of Resources and Distributive Justice" (John Mather); "Quality Assurance as an Aid to Ethical Decision Making in Disability Management: Lessons from Recent Ethical Issues Involving Disadvantaged Groups in New Zealand" (Peter Gow); "Disability and Ethical Issues: A Point of View from the Netherlands" (Yolan Koster-Dreese); "Who Shall Live or How Shall They Live? Consumer and Professional Perspectives on Treatment/Non-Treatment Decisions" (Joseph Kaufert and Patricia Kaufert); and "Debates across Social Movements on Reproductive Technologies, Genetic Engineering, and Eugenics" (Theresia Degener). Conference commentaries include: "The Meeting of Disability and Bioethics: A Beginning Rapprochement" (Adrienne Asch); "A Plea for More Dialogue: Commentary on Ethics Conference" (Robert Slater); "Healing Our Wounds" (Martha Lentz Walker); "Theories and Values: Ethics and Contrasting Perspectives on Disability" (Harlan Hahn); and "Current Example of Ethical Dilemma" (Susan Lacetti). Selected additional papers include: "High-tech Medicine Is Basic Care" (Frederick Abrams); "Prevention of Disabilities as a Medical Question" (G. Schioler); "The Ethics of Disability Prevention: A Parent's Point of View" (Mrs. J. Baker); "A Reference Matrix for Issues of Life and Personhood" (Mike Miles); "Nazi Scientists and Ethics of Today" (Isabel Wilkerson); "Ethical and Policy Issues in Rehabilitation Medicine (Hastings Center Report)" (Arthur Caplan et al.); and "Differing Approaches to Prevention of Disability and Treatment of Impaired Infants Creates Controversies Worldwide" (Barbara Duncan). (JDD). (shrink)

Most theists believe that they will survive death. Indeed, they believe that any given person will survive death and persist into an afterlife while remaining the very same person. In light of this belief, one might ask: how—or, in virtue of what—do people survive death? Perhaps the most natural way to answer this question is by appealing to some general account of personal identity through time. That way one can say that people persist through the time of their death in (...) the same way that people persist through time in general. Then the obvious question is: how—or, in virtue of what—do people persist through time in general? Many different answers to this question have been proposed. Some philosophers think that personal identity through time consists in something, such as psychological or biological continuity. They think that there are informative necessary and sufficient conditions—i.e., criteria—for personal identity through time. These philosophers are criterialists. Other philosophers are anti-criterialists. Anti-criterialists believe that people persist through time, but they deny that there are any informative criteria for personal identity through time. In this paper I develop a challenge to anti-criterialism. I begin by spelling out the commitments of anti-criterialism. Then I argue that there are good reasons for anyone to reject anti-criterialism. And then I argue that theists have special reasons to reject anti-criterialism (This is particularly important and noteworthy because a substantial portion of those who defend anti-criterialism are theists. Examples include [but may not be limited to] Trenton Merricks, Richard Swinburne, Joseph Butler, and Thomas Reid). I conclude that there is an informative criterion for personal identity through time and death, even if we haven’t heard of it yet. (shrink)

While engaging in rich discussion, Conspiracy Theories analyzes current arguments and evidence while providing real-world examples so students can contextualize and visualize the debates. Each chapter addresses important current questions, provides conceptual tools, defines important terms, and introduces the appropriate methods of analysis.

The main idea in this series of essays is that subjective awareness depends upon the intralaminar nuclei of each thalmus. This implies that the internal structure and external relations of ILN make subjective awareness possible. An array of material relevant to this proposal was briefly reviewed in Part I. This Part II considers in more detail some semantic aspects and a bit of philosophic background as these pertain to propositions 0, 1, and 2 of Part I. Part II should be (...) read in conjunction with Part I. (shrink)

How certain neural mechanisms momentarily endow with the subjective awareness percepts and affects represented elsewhere is more likely to be clarified when structures essential to Mc are identified. The loss of C with bilateral thalmic lesions involving the intralaminar nuclei contrasts with retention of C after large cortical ablations depriving C of specific contents. A role of ILN in the perception of primitive sensations is suggested by their afference of directly ascending pathways. A role for ILN in awareness of cortical (...) activity is suggested by their widespread afference from cortex, a property shared with striatum. A role for ILN in volition is suggested by their heavy projection to striatum. Unlike striatum, ILN also project widely to almost all neocortex, enabling an effect on ideation; this last property is in common with other structures but none of them has the same direct cortical afference. And passage through the reticular nucleus of ILN efferents to cortex could impact the attention-selective action of nRt. It is suggested that the quickest route to a better understanding of C involves more intensive study of ILN. No other structure seems, in the light of our current knowledge, a more likely site for Mc. (shrink)

Variant Creutzfeldt–Jakob disease is a fatal, transmissible, neurodegenerative disorder for which there is currently no effective treatment. vCJD arose from the zoonotic spread of bovine spongiform encephalopathy. There is now compelling evidence for human to human transmission through blood transfusions from presymptomatic carriers and experts are warning that the real epidemic may be yet to come. Imperatives exist for the development of reliable, non-invasive presymptomatic diagnostic tests. Research into such tests is well advanced. In this article the ethical implications of (...) the availability of these tests are elaborated and comparisons drawn with predictive genetic testing for Huntington’s disease and screening for HIV. Paramount to considerations is the issue of whom to test, weighing up respect for personal autonomy against obligations to benefit and protect society. A paradigm is proposed similar to that used for HIV screening but with unique features: compulsory testing of all blood/organ donors and individuals undergoing surgery or invasive procedures who have a significant risk of disease transmission. (shrink)

Intra-molecular connectivity (that is, chemical structure) does not emerge from computations based on fundamental quantum-mechanical principles. In order to compute molecular electronic energies (of C 3 H 4 hydrocarbons, for instance) quantum chemists must insert intra-molecular connectivity “by hand.” Some take this as an indication that chemistry cannot be reduced to physics: others consider it as evidence that quantum chemistry needs new logical foundations. Such discussions are generally synchronic rather than diachronic —that is, they neglect ‘historical’ aspects. However, systems of (...) interest to chemists generally are metastable . In many cases chemical systems of a given elemental composition may exist in any one of several different metastable states depending on the history of the system. Molecular structure generally depends on contingent historical circumstances of synthesis and separation, rather than solely or mainly on relative energies of alternative stable states, those energies in turn determined by relationships among components. Chemical structure is usually ‘kinetically-determined’ rather than ‘thermodynamically-determined.’ For instance, cyclical hydrocarbon ring-systems (as in cyclopropene) are produced only in special circumstances. Adequate theoretical treatments must take account of the persistent effects of such contingent historical events whenever they are relevant—as they generally are in chemistry. (shrink)

Ecology and sustainability are current narratives about the behavior of humans toward themselves and the environment. Ecology is defined as a science, and a philosophy of ecology has become a recognized domain of the philosophy of science. For some, sustainability is an accepted, important moral goal. In 2013, a Special Issue of the journal Sustainability dealt with many of the relevant issues. Unfortunately, the economic, ideological, and psychological barriers to ethical behavior and corresponding social action remain great as well as (...) obvious. In this paper, I propose that a new, non-standard and non-propositional logic of real processes, Logic in Reality (LIR) grounded in physics applies to the science and philosophy of these narratives and helps to explicate them. Given the ecological role of organizations and institutions, reference is often made to organizational or institutional logics as guides to ecological practice. This paper suggests that these logics are either too abstract or too informal to have an impact in a conflictual world. Recognition of the suggested new, transdisciplinary logical dimension of ecological processes may provide credibility and support to new initiatives in ecology and its philosophy. (shrink)

This volume addresses relations between macroscopic and microscopic description; essential roles of visualization and representation in chemical understanding; historical questions involving chemical concepts; the impacts of chemical ideas on wider cultural concerns; and relationships between contemporary chemistry and other sciences. The authors demonstrate, assert, or tacitly assume that chemical explanation is functionally autonomous. This volume should he of interest not only to professional chemists and philosophers, but also to workers in medicine, psychology, and other fields in which relationships between explanations (...) based on diverse levels of description and investigation are important. (Listed on Google books). (shrink)

The work is the presentation of a logical theory - Logic in Reality (LIR) - and of applications of that theory in natural science and philosophy, including ...

The main scientific problems of chemical bonding were solved half a century ago, but adequate philosophical understanding of chemical combination is yet to be achieved. Chemists routinely use important terms ("element," "atom," "molecule," "substance") with more than one meaning. This can lead to misunderstandings. Eliminativists claim that what seems to be a baseball breaking a window is merely the action of "atoms, acting in concert." They argue that statues, baseballs, and similar macroscopic things "do not exist." When macroscopic objects like (...) baseballs move, exceedingly large numbers (1025) of microscopic components coordinate their activities. Understanding how this happens requires attention to the interactions that link parts into larger units. Eliminativists say that everything that truly exists has causal relationships in addition to those of its components—"nonredundant causality." This paper holds that if a number of entities interact in such a way that the effect of that collection on test objects is different than it would have been in the absence of the interaction, then identification of that collection as a single composite agent is warranted, for purposes to which that difference is relevant. Ordinary "chemical substances" (both elementary materials such as dihydrogen and compounds such as water) fulfill this version of the requirement of nonredundant causality. Other sorts of chemical coherences, including chemical dissipative structures (e.g., flames), also fulfill that criterion. All these types of coherences qualify as "substances" (as that term is used in philosophy) even though they are not all "chemical substances.". (shrink)

In the characterization of the ArCl2 'van der Waals complex', a recognizable pattern of well-defined peaks is observed in the microwave absorption spectrum. In the control of chaos in a chemical oscillatory reaction the power spectrum progressively becomes simpler, at length yielding a single peak. Since both of these cases generate coherences that are centers of agency, they should be considered to produce new chemical entities. Applicability of this ontological approach to coherences of wider societal interest is suggested.

Longlisted for the PEN/E.O. Wilson Literary Science Writing Award A leading neuroscientist offers a history of the evolution of the brain from unicellular organisms to the complexity of animals and human beings today Renowned neuroscientist Joseph LeDoux digs into the natural history of life on earth to provide a new perspective on the similarities between us and our ancestors in deep time. This page-turning survey of the whole of terrestrial evolution sheds new light on how nervous systems evolved in (...) animals, how the brain developed, and what it means to be human. In The Deep History of Ourselves, LeDoux argues that the key to understanding human behavior lies in viewing evolution through the prism of the first living organisms. By tracking the chain of the evolutionary timeline he shows how even the earliest single-cell organisms had to solve the same problems we and our cells have to solve each day. Along the way, LeDoux explores our place in nature, how the evolution of nervous systems enhanced the ability of organisms to survive and thrive, and how the emergence of what we humans understand as consciousness made our greatest and most horrendous achievements as a species possible. (shrink)

Philosophers have long debated ‘substrate’ and ‘bundle’ theories as to how properties hold together in objects ― but have neglected to consider that every chemical entity is defined by closure of relationships among components ― here designated ‘Closure Louis de Broglie.’ That type of closure underlies the coherence of spectroscopic and chemical properties of chemical substances, and is importantly implicated in the stability and definition of entities of many other types, including those usually involved in philosophic discourse ― such as (...) roses, statues, and tennis balls. Characteristics of composites are often presumed to ‘supervene on’ properties of components. This assumption does not apply when cooperative interactions among components are significant. Once correlations dominate, then adequate descriptions must involve different entities and relationships than those that are involved in ‘fundamental-level’ description of similar but uncorrelated systems. That is to say, descriptions must involve different semantics than would be appropriate if cooperative interactions were insignificant. This is termed ‘Closure Henri Poincaré. Networks of chemical reactions that have certain types of closure of processes display properties that make other more-complex coherences possible. This is termed ‘Closure Jacques Cauvin.’ Each of these three modes of closure provides a sufficient basis for warranted recognition of causal interaction, thus each of them has epistemological significance. Other modes of epistemologically-important closure probably exist. It is important to recognize that causal efficacy generally depends on closure of relationships of constituents. (shrink)

'Fear' is used scientifically in two ways, which causes confusion: it refers to conscious feelings and to behavioral and physiological responses. Restricting the use of 'fear' to denote feelings and using 'threat-induced defensive reactions' for the responses would help avoid misunderstandings about the brain mechanisms involved.

ABSTRACT The main cause of the crisis was the behavior of the banks—largely a result of misguided incentives unrestrained by good regulation. Conservative ideology, along with unrealistic economic models of perfect information, perfect competition, and perfect markets, fostered lax regulation, and campaign contributions helped the political process along. The banks misjudged risk, wildly overleveraged, and paid their executives handsomely for being short‐sighted; lax regulation let them get away with it—putting at risk the entire economy. The mortgage brokers neglected due diligence, (...) since they would not bear the risk of default once their mortgages had been securitized and sold to others. Others can be blamed: the ratings agencies that judged subprime securities as investment grade; the Fed, which contributed low interest rates; the Bush administration, whose Iraq war and tax cuts for the rich made low interest rates necessary. But low interest rates can be a boon; it was the financial institutions that turned them into a bust. (shrink)

This paper recommends that chemistry educators shift to a different ‘idea of nature’, an alternative ‘worldview.’ Much of contemporary science and technology deals in one way or another with dynamic coherences that display novel and important properties. The notion of how the world works that such studies and practices generate (and require) is quite different from the earlier concepts that are now integrated into science education. Eventual success in meeting contemporary technological and social challenges requires general diffusion of an overall (...) outlook that focuses on creative generation of novel and useful coherences, replacing a worldview that concentrates on analysis of pre-existing items to minimum constituents. Such a shift in emphasis would amount to general adoption of a new basic model of how nature functions. Chemistry educators can and should provide leadership for this urgently-needed development. (shrink)

The advent of quantum mechanics in the early 20 th Century had profound consequences for science and mathematics, for philosophy (Schrödinger), and for logic (von Neumann). In 1968, Putnam wrote that quantum mechanics required a revolution in our understanding of logic per se. However, applications of quantum logics have been little explored outside the quantum domain. Dummett saw some implications of quantum logic for truth, but few philosophers applied similar intuitions to epistemology or ontology. Logic remained a truth-functional ’science’ of (...) correct propositional reasoning. Starting in 1935, the Franco-Romanian thinker Stéphane Lupasco described a logical system based on the inherent dialectics of energy and accordingly expressed in and applicable to complex real processes at higher levels of reality. Unfortunately, Lupasco’s fifteen major publications in French went unrecognized by mainstream logic and philosophy, and unnoticed outside a Francophone intellectual community, albeit with some translations into other Romance languages. In English, summaries of Lupasco’s logic appeared ca. 2000, but the first major treatment and extension of his system was published in 2008 (see Brenner 2008). This paper is a further attempt to establish Lupasco’s concepts as significant contributions to the history and philosophy of logic, in line with the work of Gödel, general relativity, and the ontological turn in philosophy. (shrink)

During a long and distinguished career, Belgian physical chemist Ilya Prigogine (1917–2003) pursued a coherent research program in thermodynamics, statistical mechanics, and related scientific areas. The main goal of this effort was establishing the origin of thermodynamic irreversibility (the ‘‘arrow of time’’) as local (residing in the details of the interaction of interest), rather than as global (being solely a consequence of properties of the initial singularity – the ‘‘Big Bang’’). In many publications for general audiences, he stated the opinion (...) that this scientific research had great philosophical importance. Prigogine and his colleagues considered that the most recent stages of this research program have been successful, so that the local origins of the arrow of time are now established. There is no scientific consensus as to whether or not this claim is valid. Similarly, there is no consensus on whether the competing global (initial singularity) explanation has been proven. (shrink)

Fact checking has become a prominent facet of political news coverage, but it employs a variety of objectionable methodological practices, such as treating a statement containing multiple facts as if it were a single fact and categorizing as accurate or inaccurate predictions of events yet to occur. These practices share the tacit presupposition that there cannot be genuine political debate about facts, because facts are unambiguous and not subject to interpretation. Therefore, when the black-and-white facts—as they appear to the fact (...) checkers—conflict with the claims produced by politicians, the fact checkers are able to see only (to one degree or another) “lies.” The examples of dubious fact-checking practices that we discuss show the untenability of the naïve political epistemology at work in the fact-checking branch of journalism. They may also call into question the same epistemology in journalism at large, and in politics. (shrink)

1. The problemLewis identifies the monadic property being F with the set of all actual and possible Fs; the dyadic relation R is identified with the set of actual and possible pairs of things that are related by R; and so on . 1 Egan has argued that the fact that some properties have some of their properties contingently leads to trouble: " Let @ be the actual world, in which being green is [someone's] favourite property, and let w be (...) a world in which being green is [nobody's] favourite property. Since being green is somebody's favourite property in @, it must be a member of … being somebody's favourite property. Since being green is not anybody's favourite property in w, it must not be a member of being somebody's favourite property. Contradiction. " Egan suggests identifying properties with functions from worlds to extensions. However, as Lewis and others have complained, this has the drawback of turning monadic properties into relations . 2 In this article, we shall show that the Lewisian has the resources to block the above argument while simultaneously respecting the adicity of the relevant property and the contingency of the predication without changing his theory of properties. However, our analysis reveals a hidden ambiguity in the Lewisian conception of properties, and on either disambiguation the resulting account of properties seems inadequate.2. On ‘being someone's favourite property’The phrase ‘ being someone's favourite property’ is ambiguous. Given Lewis's ontology of possibilia, where the phrase picks out a monadic property it is not one that is possessed contingently; where it picks out a property that is possessed contingently it is not one that is monadic. But the argument works only if being someone's favourite property is both monadic and possessed contingently.Why should …. (shrink)

This is the first volume dedicated solely to the topic of epistemological disjunctivism. The original essays in this volume, written by leading and up-and-coming scholars on the topic, are divided into three thematic sections. The first set of chapters addresses the historical background of epistemological disjunctivism. It features essays on ancient epistemology, Immanuel Kant, J.L. Austin, Edmund Husserl, and Ludwig Wittgenstein. The second section tackles a number contemporary issues related to epistemological disjunctivism, including its relationship with perceptual disjunctivism, radical skepticism, (...) and reasons for belief. Finally, the third group of essays extends the framework of epistemological disjunctivism to other forms of knowledge, such as testimonial knowledge, knowledge of other minds, and self-knowledge. Epistemological Disjunctivism is a timely collection that engages with an increasingly important topic in philosophy. It will appeal to researches and graduate students working in epistemology, philosophy of mind, and philosophy of perception. (shrink)

Many people believe in the power of positive thinking (i.e., how thoughts and attitude can shape their future) yet, despite a plethora of books on this subject, no previous author has credibly explained how mere thoughts are able to tangibly influence future events. To explain the connection, Dr. Donlan presents a new paradigm of nature coupled with a viable explanation of how our right cerebral hemisphere has evolved circuitry that can tap into the hidden domain of the metaphysical. To support (...) this premise, he exposes the reader to the worlds of physics, metaphysics, brain architecture, and evolution. Donlan then introduces the many problems associated with the current model and contrasts it with a new view which remedies many of the issues facing theoretical physicists today. Important to its central theme, the book's proposed paradigm supports the remarkable notion that the future can only be created with thoughts. In the final analysis, the author brings his readers through the necessary steps to put this knowledge to work to help them (pre)ordain their own realities. (shrink)

Each of these books presents a new paradigm of nature and couples it with a convincing explanation of how our right brain hemispheres have a unique ability to ...

To explain the connection, this book presents a new paradigm of nature and couples it with a convincing explanation of how our right brain hemispheres have a ...